When you think of river cruises, the first things that come to mind may be Europe’s
Danube or Rhine. However, did you know that the United States offers a wealth of
stunning river cruise destinations you can experience?
Keep reading because in this guide, we’ll explore 25 of the best U.S. destinations for
river cruises. These cruises give a unique perspective on America’s heartland and coastal regions.
New Orleans, Louisiana
The Big Easy serves as the perfect starting point for a Mississippi River cruise.
Known for its vibrant jazz scene, Creole cuisine, and French Quarter architecture,
New Orleans offers a cultural feast before you even set sail.
Don’t miss the chance to sample beignets at Café du Monde or take a stroll through the historic Garden District.
St. Louis, Missouri
Home to the iconic Gateway Arch, St. Louis stands as a testament to America’s westward expansion. This city, where the Mississippi and Missouri rivers converge,
offers a blend of Midwest charm and riverfront history.
Before embarking, consider visiting the National Blues Museum or catching a Cardinals game at Busch Stadium.
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Memphis, Tennessee
Music lovers will find their rhythm in Memphis, the birthplace of blues and rock ‘n’ roll.
A stop on many Mississippi River cruises, this city invites visitors to tour Graceland, Elvis Presley’s former home, or enjoy a world-famous barbecue on Beale Street.
The National Civil Rights Museum at the Lorraine Motel provides a sobering look at
American history.
Natchez, Mississippi
Step back in time in Natchez, a city known for its well-preserved antebellum mansions and rich Southern history. River cruise passengers can take a carriage ride through the historic district, visit the Grand Village of the Natchez Indians, or sample local brews at the Natchez Brewing Company.
The city’s location, high on the bluffs, offers spectacular views of the Mississippi.
Portland, Oregon
The City of Roses is a pathway to Columbia River cruises. You can explore Portland’s famous food cart scene or take a stroll through the lush Washington Park before embarking on your Pacific Northwest adventure.
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Astoria, Oregon
Situated at the mouth of the Columbia River, Astoria offers a perfect blend of maritime history and coastal charm. Climb the Astoria Column for panoramic views of the Pacific Ocean and Columbia River, or visit the fascinating Columbia River Maritime Museum.
The city’s Victorian-era homes add a touch of historical elegance to this rugged coastal landscape.
Nashville, Tennessee
Music City, USA is a popular stop on Cumberland River cruises. Visit the Country Music Hall of Fame, catch a show at the Grand Ole Opry, or explore the Ryman Auditorium, known as the ‘Mother Church of Country Music.’ Nashville’s hot chicken and honky-tonks provide a taste of authentic Tennessee culture.
Chattanooga, Tennessee
Known as the Scenic City, Chattanooga offers beautiful river views and outdoor adventures. Ride the Incline Railway up Lookout Mountain for breathtaking vistas,
visit the Tennessee Aquarium, or explore the Hunter Museum of American Art.
The city’s revitalized riverfront is a testament to urban renewal done right.
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Cincinnati, Ohio
The Queen City of the West boasts a rich brewing history and stunning riverfront parks. Explore the Over-the-Rhine neighborhood, visit the National Underground Railroad Freedom Center, or watch a Reds game at the Great American Ball Park.
Cincinnati’s blend of German heritage and Midwest hospitality makes it a unique stop on Ohio River cruises.
Pittsburgh, Pennsylvania
At the confluence of three rivers — the Allegheny, Monongahela, and Ohio — Pittsburgh offers a unique urban river cruise experience. Ride the Duquesne Incline for spectacular city views, visit the Andy Warhol Museum, or explore the vibrant Strip District.
The city’s transformation from an industrial powerhouse to a cultural hub is evident in its revitalized waterfront.
Galena, Illinois
This charming town on the Mississippi River is known for its well-preserved 19th- century architecture. You can tour Ulysses S. Grant’s home or shop for antiques on Main Street before your river adventure.
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Hannibal, Missouri
Mark Twain’s boyhood home is a delightful stop on Mississippi River cruises. Explore the Mark Twain Boyhood Home & Museum, take a scenic cave tour, or enjoy a riverboat dinner cruise.
The town’s connection to one of America’s greatest authors gives it a unique literary charm.
Vicksburg, Mississippi
This historic city played a crucial role in the Civil War and offers fascinating insights into Southern history. Tour the Vicksburg National Military Park, visit the Old Court House Museum, or try your luck at one of the riverboat casinos.
The city’s strategic location on the Mississippi River bluffs explains its historical significance.
Albany, New York
The capital of New York State is a gateway to Hudson River cruises. Explore the impressive New York State Capitol building, visit the Albany Institute of History and
Art, or take a stroll through Washington Park.
Albany’s blend of political history and cultural attractions makes it a captivating starting point for river journeys.
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Sacramento, California
California’s capital city offers a perfect starting point for Sacramento River cruises.
You can visit the California State Railroad Museum or explore the historic Old Sacramento district before setting sail.
Baton Rouge, Louisiana
Louisiana’s capital city blends Southern charm with rich history. Tour the Old State
Capitol, visit the LSU Rural Life Museum, or explore the USS KIDD Veterans Museum.
Baton Rouge’s location on a bluff overlooking the Mississippi River offers both scenic beauty and strategic importance.
St. Paul, Minnesota
The Twin Cities provide numerous cultural attractions at the headwaters of the Mississippi. You can visit the Science Museum of Minnesota or stroll through the beautiful Como Park before your river journey.
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Dubuque, Iowa
This picturesque river town offers stunning bluff views and a rich maritime history.
Ride the Fenelon Place Elevator for panoramic views, visit the National Mississippi
River Museum & Aquarium, or explore the Crystal Lake Cave.
Dubuque’s blend of natural beauty and cultural attractions makes it a hidden gem on Mississippi River cruises.
La Crosse, Wisconsin
Nestled between river bluffs, La Crosse offers scenic beauty and outdoor recreation.
Hike in Grandad Bluff Park, visit the Dahl Auto Museum, or take a cruise on the La
Crosse Queen paddle wheeler.
The city’s location in the Driftless Area provides unique landscapes not seen elsewhere along the Mississippi.
Cape Girardeau, Missouri
Known as the City of Roses, Cape Girardeau offers a charming riverfront and rich history. Explore the Trail of Tears State Park, visit the Southeast Missouri State
University River Campus, or take a mural tour downtown.
The city’s flood murals provide a unique outdoor art gallery depicting local history.
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Paducah, Kentucky
This UNESCO Creative City is known for its vibrant arts scene and quilt museum.
Explore the National Quilt Museum, stroll through the charming Lowertown Arts District, or visit the River Discovery Center.
Paducah’s location at the confluence of the Ohio and Tennessee Rivers makes it a strategic stop on river cruises.
The Dalles, Oregon
This historic town on the Columbia River offers stunning gorge views and rich Native
American history. Visit the Columbia Gorge Discovery Center, tour a local winery, or explore the Fort Dalles Museum.
The Dalles’ position at the end of the Oregon Trail gives it significant historical importance.
Red Wing, Minnesota
Famous for its pottery and boots, Red Wing offers small-town charm on the Mississippi. Visit the Red Wing Shoe Store & Museum, hike in Barn Bluff Park, or explore the Pottery Museum of Red Wing.
The town’s scenic beauty and industrial heritage make it a fascinating stop on Upper Mississippi cruises.
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Madison, Indiana
This charming river town boasts the largest contiguous National Historic Landmark District in the U.S. Tour historic mansions, visit the Lanier Mansion State Historic Site, or enjoy the view from the Ohio River overlook.
Madison’s well-preserved 19th- century architecture provides a glimpse into America’s past.
Fort Benton, Montana
Known as the ‘Birthplace of Montana,’ Fort Benton offers a glimpse into frontier life on the Missouri River. Visit the Museum of the Upper Missouri, explore the Old Fort, or take a walk along the historic levee.
As the head of navigation on the Missouri, Fort Benton played a crucial role in the settlement of the American West.
Your Unique River Cruise Awaits
So, there we have it. Whether you’re a history buff, nature lover, or just like to
experience a new culture,, river cruises offer a great way to explore the heart of
America.
So why not trade the bustling highways for serene waterways on your next vacation?
You’ll gain a new perspective on familiar landscapes and perhaps discover hidden gems along the way.
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